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Target
Dihydrofolate reductase
Ligand
BDBM50029758
Substrate
n/a
Meas. Tech.
ChEMBL_52981 (CHEMBL876710)
IC50
6±n/a nM
Citation
 Queener, SF New drug developments for opportunistic infections in immunosuppressed patients: Pneumocystis carinii. J Med Chem 38:4739-59 (1996) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
DYR_PNECA | Dihydrofolate Reductase (DHFR) | Dihydrofolate reductase | Dihydrofolate reductase; P. carinii vs rat | Tetrahydrofolate dehydrogenase
Type:
Enzyme
Mol. Mass.:
23891.29
Organism:
Pneumocystis carinii
Description:
n/a
Residue:
206
Sequence:
MNQQKSLTLIVALTTSYGIGRSNSLPWKLKKEISYFKRVTSFVPTFDSFESMNVVLMGRKTWESIPLQFRPLKGRINVVITRNESLDLGNGIHSAKSLDHALELLYRTYGSESSVQINRIFVIGGAQLYKAAMDHPKLDRIMATIIYKDIHCDVFFPLKFRDKEWSSVWKKEKHSDLESWVGTKVPHGKINEDGFDYEFEMWTRDL
  
Inhibitor
Name:
BDBM50029758
Synonyms:
3-(2,4-Dichloro-benzyl)-3H-3,5,6,8-tetraaza-cyclopenta[a]naphthalene-7,9-diamine | CHEMBL145628
Type:
Small organic molecule
Emp. Form.:
C16H12Cl2N6
Mol. Mass.:
359.213
SMILES:
Nc1nc(N)c2c3ccn(Cc4ccc(Cl)cc4Cl)c3cnc2n1
Structure:
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