Reaction Details Report a problem with these data
Target
Glutamate--cysteine ligase
Ligand
BDBM50487312
Substrate
n/a
Meas. Tech.
ChEMBL_911964 (CHEMBL3058795)
Ki
7700000±n/a nM
Citation
  TBA Med Chem Res 13:707-723 (2004)    Article 
Target
Name:
Glutamate--cysteine ligase
Synonyms:
6.3.2.2 | GCS | GSH1_ONCVO | Gamma-ECS | Gamma-glutamylcysteine synthetase | Glutamate--cysteine ligase | gcs-1
Type:
PROTEIN
Mol. Mass.:
74197.10
Organism:
Onchocerca volvulus
Description:
ChEMBL_106657
Residue:
652
Sequence:
MGLLTLGTPLPWNETVPYVDYIKEHGIAQFIALYHRLKGREGDQLKWGDEIEYTIVKFDDDAKRVRVSLRAEELLHQLQAGEELNALLGNENCCLWRPEFASYMIEGTPGAPYGGLLACFNVVESNMISRRAEVTRLLENGESIMSISFPALGTPDFTSPPYEPRPDDINSFGCSLFFPDEVIYGGHPRFRNLVRNIRQRRGEKVAINVPIYKDINTPSPYQEDFTKAKDGGQAARAAKSDHIYMDHMGFGMGCCCLQVTFQAVNIDEARWLYDQLTPITPVLLALSAATPVFRSRLADVDSRWDVISASVDDRTAEERGLVPLKNNKFVLEKSRYDTTDCYIYPCSESYNDIPLQYDDKIYKQLIDGGIDDLLAQHIAHMFIRDPLQVFRERIEQDDTKSTEHFETVQSSNWMNMRFKPPPPDSEIGWRVEFRPSEVQLTDFENAAYCCFVVLLTRVMISFRITLILPISALTENMKRAQRRNAVLEQKLLFRKGIATCNSPPCARGAGCTLESDDVVEMTVNEIINGNGNDFPGLIPLMRQYLDSADVDVDSRCTVSQYLSFIQKRASGELQTLAAWMREFISEHPEYKHDSYVGDRIIYDMLKEMDRISKGEISCPKLLGDYCTKTDSRIPMAVRRAEEKLIVSTKKQS
  
Inhibitor
Name:
BDBM50487312
Synonyms:
BUTHIONINE SULFOXIME
Type:
Small organic molecule
Emp. Form.:
C8H18N2O3S
Mol. Mass.:
222.305
SMILES:
CCCCS(=N)(=O)CC[C@H](N)C(O)=O
Structure:
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