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Target
Prostaglandin F2-alpha receptor
Ligand
BDBM50490454
Substrate
n/a
Meas. Tech.
ChEMBL_939168 (CHEMBL2329240)
EC50
<5012±n/a nM
Citation
 Long, DD; Frieman, B; Hegde, SS; Hill, CM; Jiang, L; Kintz, S; Marquess, DG; Purkey, H; Shaw, JP; Steinfeld, T; Wilson, MS; Wrench, K A multivalent approach towards linked dual-pharmacology prostaglandin F receptor agonist/carbonic anhydrase-II inhibitors for the treatment of glaucoma. Bioorg Med Chem Lett 23:939-43 (2013) [PubMed]  Article 
Target
Name:
Prostaglandin F2-alpha receptor
Synonyms:
PF2R_MOUSE | ProstaglandinF2Alpha | Ptgfr
Type:
Enzyme Catalytic Domain
Mol. Mass.:
40714.02
Organism:
Mouse
Description:
ProstaglandinF2Alpha PTGFR MOUSE::P43117
Residue:
366
Sequence:
MSMNSSKQPVSPAAGLIANTTCQTENRLSVFFSIIFMTVGILSNSLAIAILMKAYQRFRQKSKASFLLLASGLVITDFFGHLINGGIAVFVYASDKDWIRFDQSNILCSIFGISMVFSGLCPLFLGSAMAIERCIGVTNPIFHSTKITSKHVKMILSGVCMFAVFVAVLPILGHRDYQIQASRTWCFYNTEHIEDWEDRFYLLFFSFLGLLALGVSFSCNAVTGVTLLRVKFRSQQHRQGRSHHLEMIIQLLAIMCVSCVCWSPFLVTMANIAINGNNSPVTCETTLFALRMATWNQILDPWVYILLRKAVLRNLYKLASRCCGVNIISLHIWELSSIKNSLKVAAISESPAAEKESQQASSEAGL
  
Inhibitor
Name:
BDBM50490454
Synonyms:
CHEMBL2325981
Type:
Small organic molecule
Emp. Form.:
C20H30N4O7S2
Mol. Mass.:
502.605
SMILES:
CC(C)OC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\C(=O)Nc1nnc(s1)S(N)(=O)=O |r|
Structure:
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