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Target
Adenosine receptor A1
Ligand
BDBM50494548
Substrate
n/a
Meas. Tech.
ChEMBL_1278709 (CHEMBL3096083)
Ki
>25000±n/a nM
Citation
 Koch, P; Akkari, R; Brunschweiger, A; Borrmann, T; Schlenk, M; Küppers, P; Köse, M; Radjainia, H; Hockemeyer, J; Drabczy?ska, A; Kie?-Kononowicz, K; Müller, CE 1,3-Dialkyl-substituted tetrahydropyrimido[1,2-f]purine-2,4-diones as multiple target drugs for the potential treatment of neurodegenerative diseases. Bioorg Med Chem 21:7435-52 (2013) [PubMed]  Article 
Target
Name:
Adenosine receptor A1
Synonyms:
AA1R_RAT | ADENOSINE A1 | ADENOSINE A1 high | ADENOSINE A1 low | Adenosine A1 receptor (A1) | Adenosine receptor | Adenosine receptors A1 | Adora1
Type:
Protein
Mol. Mass.:
36704.13
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
326
Sequence:
MPPYISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSVVEQDWRANGSVGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTFLKIWNDHFRCQPKPPIDEDLPEEKAED
  
Inhibitor
Name:
BDBM50494548
Synonyms:
CHEMBL3093328
Type:
Small organic molecule
Emp. Form.:
C16H16FN5O2
Mol. Mass.:
329.3289
SMILES:
Cn1c2nc3N(CCCn3c2c(=O)n(C)c1=O)c1ccc(F)cc1
Structure:
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