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Target
Purine nucleoside phosphorylase
Ligand
BDBM50042800
Substrate
n/a
Meas. Tech.
ChEMBL_153319 (CHEMBL760055)
IC50
47±n/a nM
Citation
 Secrist, JA; Niwas, S; Rose, JD; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE; Montgomery, JA Structure-based design of inhibitors of purine nucleoside phosphorylase. 2. 9-Alicyclic and 9-heteroalicyclic derivatives of 9-deazaguanine. J Med Chem 36:1847-54 (1993) [PubMed]  Article 
Target
Name:
Purine nucleoside phosphorylase
Synonyms:
Inosine phosphorylase | NP | PNP | PNPH_BOVIN | Purine Nucleoside Phosphorylase (PNP) | Purine nucleoside phosphorylase
Type:
Enzyme
Mol. Mass.:
32035.18
Organism:
Bovine
Description:
n/a
Residue:
289
Sequence:
MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG
  
Inhibitor
Name:
BDBM50042800
Synonyms:
2-Amino-7-cyclohexylmethyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one | CHEMBL299952
Type:
Small organic molecule
Emp. Form.:
C13H18N4O
Mol. Mass.:
246.3082
SMILES:
Nc1nc2c(CC3CCCCC3)c[nH]c2c(=O)[nH]1
Structure:
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