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Target
Reverse transcriptase
Ligand
BDBM50476420
Substrate
n/a
Meas. Tech.
ChEMBL_1661651 (CHEMBL4011263)
IC50
>100000±n/a nM
Citation
 Xue, P; Lu, HH; Zhu, YY; Ju, XL; Pannecouque, C; Zheng, XJ; Liu, GY; Zhang, XL; Gu, SX Design and synthesis of hybrids of diarylpyrimidines and diketo acids as HIV-1 inhibitors. Bioorg Med Chem Lett 27:1640-1643 (2017) [PubMed]  Article 
Target
Name:
Reverse transcriptase
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
29598.37
Organism:
Human immunodeficiency virus 1
Description:
Q9WKE8
Residue:
254
Sequence:
PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVN
  
Inhibitor
Name:
BDBM50476420
Synonyms:
CHEMBL242883
Type:
Small organic molecule
Emp. Form.:
C17H14O4
Mol. Mass.:
282.2907
SMILES:
OC(=O)C(\O)=C\C(=O)c1cccc(Cc2ccccc2)c1
Structure:
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