Reaction Details Report a problem with these data
Target
Adenosine receptor A1
Ligand
BDBM50053172
Substrate
n/a
Meas. Tech.
ChEMBL_29283 (CHEMBL640344)
IC50
583300±n/a nM
Citation
 Dorigo, P; Fraccarollo, D; Santostasi, G; Maragno, I; Floreani, M; Borea, PA; Mosti, L; Sansebastiano, L; Fossa, P; Orsini, F; Benetollo, F; Bombieri, G Synthesis and cardiotonic activity of novel pyrimidine derivatives: crystallographic and quantum chemical studies. J Med Chem 39:3671-83 (1996) [PubMed]  Article 
Target
Name:
Adenosine receptor A1
Synonyms:
A1 adenosine receptor | AA1R_CAVPO | ADENOSINE A1 | ADENOSINE A1 high | ADENOSINE A1 low | ADORA1 | Adenosine A1 receptor | Adenosine Receptor A1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36501.39
Organism:
GUINEA PIG
Description:
ADENOSINE A1 ADORA1 GUINEA PIG::P47745
Residue:
326
Sequence:
MPHSVSAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIASLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVVTPRRAAVAIAGCWILSLVVGLTPMFGWNNLSKIEMAWAANGSVGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLSKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPTCHKPTILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPEPPIDEDLPEEKVDD
  
Inhibitor
Name:
BDBM50053172
Synonyms:
4-Benzyl-2-dimethylamino-pyrimidine-5-carboxylic acid | CHEMBL122615
Type:
Small organic molecule
Emp. Form.:
C14H15N3O2
Mol. Mass.:
257.2878
SMILES:
CN(C)c1ncc(C(O)=O)c(Cc2ccccc2)n1
Structure:
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