Reaction Details Report a problem with these data
Target
Melatonin receptor type 1A
Ligand
BDBM50043289
Substrate
n/a
Meas. Tech.
ChEMBL_1824698 (CHEMBL4324462)
Ki
11±n/a nM
Citation
 Wang, SY; Shi, XC; Laborda, P Indole-based melatonin analogues: Synthetic approaches and biological activity. Eur J Med Chem 185:0 (2020) [PubMed]  Article 
Target
Name:
Melatonin receptor type 1A
Synonyms:
MTNR1A | MTNR1A protein | MTR1A_HUMAN | Mel-1A-R | Mel1a melatonin receptor | Melatonin 1A | Melatonin receptor | Melatonin receptor 1A | Melatonin receptor type 1 (MT1) | Melatonin receptor type 1A
Type:
Enzyme
Mol. Mass.:
39392.94
Organism:
Homo sapiens (Human)
Description:
P48039
Residue:
350
Sequence:
MQGNGSALPNASQPVLRGDGARPSWLASALACVLIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLMSIFNNGWNLGYLHCQVSGFLMGLSVIGSIFNITGIAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAVLPNLRAGTLQYDPRIYSCTFAQSVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQRVKPDRKPKLKPQDFRNFVTMFVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQNFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWKPSPLMTNNNVVKVDSV
  
Inhibitor
Name:
BDBM50043289
Synonyms:
CHEMBL34730 | N-[2-(6-Chloro-5-methoxy-1H-indol-3-yl)-ethyl]-acetamide | N-[2-(6-Chloro-5-methoxy-1H-indol-3-yl)-ethyl]-acetamide(6-Chloromelatonin) | melatonin, 6-Chloro
Type:
Small organic molecule
Emp. Form.:
C13H15ClN2O2
Mol. Mass.:
266.723
SMILES:
COc1cc2c(CCNC(C)=O)c[nH]c2cc1Cl
Structure:
Search PDB for entries with ligand similarity: