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Target
Interferon regulatory factor 3
Ligand
BDBM50506263
Substrate
n/a
Meas. Tech.
ChEMBL_1825358 (CHEMBL4325122)
EC50
>100000±n/a nM
Citation
 Xi, Q; Wang, M; Jia, W; Yang, M; Hu, J; Jin, J; Chen, X; Yin, D; Wang, X Design, Synthesis, and Biological Evaluation of Amidobenzimidazole Derivatives as Stimulator of Interferon Genes (STING) Receptor Agonists. J Med Chem 63:260-282 (2020) [PubMed]  Article 
Target
Name:
Interferon regulatory factor 3
Synonyms:
IRF-3 | IRF3 | IRF3_HUMAN | Interferon regulatory factor 3
Type:
PROTEIN
Mol. Mass.:
47209.13
Organism:
Homo sapiens
Description:
ChEMBL_119043
Residue:
427
Sequence:
MGTPKPRILPWLVSQLDLGQLEGVAWVNKSRTRFRIPWKHGLRQDAQQEDFGIFQAWAEATGAYVPGRDKPDLPTWKRNFRSALNRKEGLRLAEDRSKDPHDPHKIYEFVNSGVGDFSQPDTSPDTNGGGSTSDTQEDILDELLGNMVLAPLPDPGPPSLAVAPEPCPQPLRSPSLDNPTPFPNLGPSENPLKRLLVPGEEWEFEVTAFYRGRQVFQQTISCPEGLRLVGSEVGDRTLPGWPVTLPDPGMSLTDRGVMSYVRHVLSCLGGGLALWRAGQWLWAQRLGHCHTYWAVSEELLPNSGHGPDGEVPKDKEGGVFDLGPFIVDLITFTEGSGRSPRYALWFCVGESWPQDQPWTKRLVMVKVVPTCLRALVEMARVGGASSLENTVDLHISNSHPLSLTSDQYKAYLQDLVEGMDFQGPGES
  
Inhibitor
Name:
BDBM50506263
Synonyms:
CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP
Type:
Small organic molecule
Emp. Form.:
C20H24N10O13P2
Mol. Mass.:
674.4113
SMILES:
[H][C@]12COP(O)(=O)O[C@@]3([H])[C@@H](O)[C@@H](O[C@]3([H])COP(O)(=O)O[C@@]([H])([C@@H](O1)n1cnc3c1nc(N)[nH]c3=O)[C@@H]2O)n1cnc2c(N)ncnc12 |r|
Structure:
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