Target
Receptor-interacting serine/threonine-protein kinase 1
Ligand
BDBM50513021
Substrate
n/a
Meas. Tech.
ChEMBL_1851533 (CHEMBL4352157)
IC50
794±n/a nM
Citation
 Harris, PAFaucher, NGeorge, NEidam, PMKing, BWWhite, GVAnderson, NABandyopadhyay, DBeal, AMBeneton, VBerger, SBCampobasso, NCampos, SCapriotti, CACox, JADaugan, ADonche, FFouchet, MHFinger, JNGeddes, BGough, PJGrondin, PHoffman, BLHoffman, SJHutchinson, SEJeong, JUJigorel, ELamoureux, PLeister, LKLich, JDMahajan, MKMeslamani, JMosley, JENagilla, RNassau, PMNg, SLOuellette, MTPasikanti, KKPotvain, FReilly, MARivera, EJSautet, SSchaeffer, MCSehon, CASun, HThorpe, JHTotoritis, RDWard, PWellaway, NWisnoski, DDWoolven, JMBertin, JMarquis, RW Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase. J Med Chem 62:5096-5110 (2019) [PubMed]  Article 
Target
Name:
Receptor-interacting serine/threonine-protein kinase 1
Synonyms:
Cell death protein RIP | RIP | RIP-1 | RIP1 | RIPK1 | RIPK1_HUMAN | Receptor-interacting protein 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
75926.99
Organism:
Homo sapiens (Human)
Description:
Q13546
Residue:
671
Sequence:
MQPDMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEEDVKSLKKEYSNENAVVKRMQSLQLDCVAVPSSRSNSATEQPGSLHSSQGLGMGPVEESWFAPSLEHPQEENEPSLQSKLQDEANYHLYGSRMDRQTKQQPRQNVAYNREEERRRRVSHDPFAQQRPYENFQNTEGKGTAYSSAASHGNAVHQPSGLTSQPQVLYQNNGLYSSHGFGTRPLDPGTAGPRVWYRPIPSHMPSLHNIPVPETNYLGNTPTMPFSSLPPTDESIKYTIYNSTGIQIGAYNYMEIGGTSSSLLDSTNTNFKEEPAAKYQAIFDNTTSLTDKHLDPIRENLGKHWKNCARKLGFTQSQIDEIDHDYERDGLKEKVYQMLQKWVMREGIKGATVGKLAQALHQCSRIDLLSSLIYVSQN
  
Inhibitor
Name:
BDBM50513021
Synonyms:
CHEMBL4590117
Type:
Small organic molecule
Emp. Form.:
C14H24N2O
Mol. Mass.:
236.3532
SMILES:
CC(C)(C)C(=O)N1N=CCC1C1CCCCC1 |c:7|
Structure:
Search PDB for entries with ligand similarity: