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Target
Plasminogen
Ligand
BDBM50514077
Substrate
n/a
Meas. Tech.
ChEMBL_1855589 (CHEMBL4356318)
IC50
1.000000±n/a nM
Citation
 Steinmetzer, T; Pilgram, O; Wenzel, BM; Wiedemeyer, SJA Fibrinolysis Inhibitors: Potential Drugs for the Treatment and Prevention of Bleeding. J Med Chem 63:1445-1472 (2020) [PubMed]  Article 
Target
Name:
Plasminogen
Synonyms:
Activation peptide | Angiostatin | PLG | PLMN_HUMAN | Plasmin | Plasmin heavy chain A | Plasmin heavy chain A, short form | Plasmin light chain B
Type:
Enzyme
Mol. Mass.:
90579.18
Organism:
Human
Description:
n/a
Residue:
810
Sequence:
MEHKEVVLLLLLFLKSGQGEPLDDYVNTQGASLFSVTKKQLGAGSIEECAAKCEEDEEFTCRAFQYHSKEQQCVIMAENRKSSIIIRMRDVVLFEKKVYLSECKTGNGKNYRGTMSKTKNGITCQKWSSTSPHRPRFSPATHPSEGLEENYCRNPDNDPQGPWCYTTDPEKRYDYCDILECEEECMHCSGENYDGKISKTMSGLECQAWDSQSPHAHGYIPSKFPNKNLKKNYCRNPDRELRPWCFTTDPNKRWELCDIPRCTTPPPSSGPTYQCLKGTGENYRGNVAVTVSGHTCQHWSAQTPHTHNRTPENFPCKNLDENYCRNPDGKRAPWCHTTNSQVRWEYCKIPSCDSSPVSTEQLAPTAPPELTPVVQDCYHGDGQSYRGTSSTTTTGKKCQSWSSMTPHRHQKTPENYPNAGLTMNYCRNPDADKGPWCFTTDPSVRWEYCNLKKCSGTEASVVAPPPVVLLPDVETPSEEDCMFGNGKGYRGKRATTVTGTPCQDWAAQEPHRHSIFTPETNPRAGLEKNYCRNPDGDVGGPWCYTTNPRKLYDYCDVPQCAAPSFDCGKPQVEPKKCPGRVVGGCVAHPHSWPWQVSLRTRFGMHFCGGTLISPEWVLTAAHCLEKSPRPSSYKVILGAHQEVNLEPHVQEIEVSRLFLEPTRKDIALLKLSSPAVITDKVIPACLPSPNYVVADRTECFITGWGETQGTFGAGLLKEAQLPVIENKVCNRYEFLNGRVQSTELCAGHLAGGTDSCQGDSGGPLVCFEKDKYILQGVTSWGLGCARPNKPGVYVRVSRFVTWIEGVMRNN
  
Inhibitor
Name:
BDBM50514077
Synonyms:
CHEMBL4475211
Type:
Small organic molecule
Emp. Form.:
C36H38ClN5O6
Mol. Mass.:
672.17
SMILES:
CNC(=O)c1ccc(NC(=O)[C@H](Cc2ccc(cc2)-c2cc3[nH]cc(C(O)=O)c(=O)c3cc2C)NC(=O)[C@H]2CC[C@H](CN)CC2)cc1Cl |r,wU:40.43,wD:37.39,11.11,(20.68,-5.12,;19.35,-5.89,;18.02,-5.13,;18.02,-3.59,;16.68,-5.9,;16.68,-7.44,;15.35,-8.22,;14.02,-7.44,;12.68,-8.21,;11.35,-7.44,;11.35,-5.9,;10.01,-8.21,;10.01,-9.75,;11.35,-10.52,;11.34,-12.06,;12.67,-12.83,;14.01,-12.06,;14,-10.51,;12.67,-9.75,;15.34,-12.83,;15.34,-14.37,;16.67,-15.13,;16.67,-16.66,;18,-17.45,;19.33,-16.68,;20.66,-17.46,;22,-16.69,;20.65,-19,;19.35,-15.13,;20.67,-14.37,;18.01,-14.37,;18.01,-12.82,;16.67,-12.06,;16.66,-10.52,;8.69,-7.44,;7.35,-8.21,;6.02,-7.44,;7.35,-9.75,;6.02,-10.52,;6.02,-12.06,;7.35,-12.83,;7.35,-14.37,;6.02,-15.14,;8.68,-12.06,;8.68,-10.52,;14.01,-5.91,;15.34,-5.14,;15.34,-3.6,)|
Structure:
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