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Target
Histone deacetylase 1
Ligand
BDBM50517219
Substrate
n/a
Meas. Tech.
ChEMBL_1867764 (CHEMBL4368739)
Ki
11900±n/a nM
Citation
 Asfaha, Y; Schrenk, C; Alves Avelar, LA; Hamacher, A; Pflieger, M; Kassack, MU; Kurz, T Recent advances in class IIa histone deacetylases research. Bioorg Med Chem 27:0 (2019) [PubMed]  Article 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50517219
Synonyms:
CHEMBL4456269
Type:
Small organic molecule
Emp. Form.:
C24H26N4O3S
Mol. Mass.:
450.553
SMILES:
CN1CCC(CNC(=O)c2cccc(c2)C(=O)NO)(CC1)c1nc(cs1)-c1ccccc1
Structure:
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