Reaction Details Report a problem with these data
Target
Aldo-keto reductase family 1 member B10
Ligand
BDBM50519874
Substrate
n/a
Meas. Tech.
ChEMBL_1878641 (CHEMBL4380035)
IC50
56240±n/a nM
Citation
 Hlavá?, M; Ková?iková, L; Prnová, M?; ?ramel, P; Addová, G; Májeková, M; Hanquet, G; Bohá?, A; ?tefek, M Development of Novel Oxotriazinoindole Inhibitors of Aldose Reductase: Isosteric Sulfur/Oxygen Replacement in the Thioxotriazinoindole Cemtirestat Markedly Improved Inhibition Selectivity. J Med Chem 63:369-381 (2020) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B10
Synonyms:
AK1BA_HUMAN | AKR1B10 | AKR1B11 | ARL-1 | ARP | Aldo-keto reductase family 1 member B10 | Aldo-keto reductase family 1 member B10 (AKR1B10) | Aldo-keto reductase family member 1B10 (AKR1B10) | Aldose reductase-like | Aldose reductase-related protein | SI reductase | Small intestine reductase | hARP
Type:
Protein
Mol. Mass.:
36024.67
Organism:
Homo sapiens (Human)
Description:
O60218. 1ZUA; 4JII; 4GQ0
Residue:
316
Sequence:
MATFVELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQEKIQEKAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSGDDLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEKLLNKPGLKYKPVTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAKHKKTAAQVLIRFHIQRNVIVIPKSVTPARIVENIQVFDFKLSDEEMATILSFNRNWRACNVLQSSHLEDYPFNAEY
  
Inhibitor
Name:
BDBM50519874
Synonyms:
CHEMBL4582264
Type:
Small organic molecule
Emp. Form.:
C11H8N4O3
Mol. Mass.:
244.2062
SMILES:
OC(=O)Cn1c2ccccc2c2n[nH]c(=O)nc12
Structure:
Search PDB for entries with ligand similarity: