Reaction Details Report a problem with these data
Target
Prostaglandin E2 receptor EP1 subtype
Ligand
BDBM50520101
Substrate
n/a
Meas. Tech.
ChEMBL_1879037 (CHEMBL4380431)
IC50
>10000±n/a nM
Citation
 Yang, JJ; Yu, WW; Hu, LL; Liu, WJ; Lin, XH; Wang, W; Zhang, Q; Wang, PL; Tang, SW; Wang, X; Liu, M; Lu, W; Zhang, HK Discovery and Characterization of 1 J Med Chem 63:569-590 (2020) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP1 subtype
Synonyms:
PE2R1_HUMAN | PGE receptor, EP1 subtype | PTGER1 | Prostaglandin E2 receptor | Prostaglandin E2 receptor EP1 subtype | Prostaglandin E2 receptor EP1 subtype (EP1) | Prostanoid EP1 receptor
Type:
Enzyme
Mol. Mass.:
41834.57
Organism:
Homo sapiens (Human)
Description:
P34995
Residue:
402
Sequence:
MSPCGPLNLSLAGEATTCAAPWVPNTSAVPPSGASPALPIFSMTLGAVSNLLALALLAQAAGRLRRRRSAATFLLFVASLLATDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTRPLLHAARVSVARARLALAAVAAVALAVALLPLARVGRYELQYPGTWCFIGLGPPGGWRQALLAGLFASLGLVALLAALVCNTLSGLALLRARWRRRSRRPPPASGPDSRRRWGAHGPRSASASSASSIASASTFFGGSRSSGSARRARAHDVEMVGQLVGIMVVSCICWSPMLVLVALAVGGWSSTSLQRPLFLAVRLASWNQILDPWVYILLRQAVLRQLLRLLPPRAGAKGGPAGLGLTPSAWEASSLRSSRHSGLSHF
  
Inhibitor
Name:
BDBM50520101
Synonyms:
CHEMBL4439228
Type:
Small organic molecule
Emp. Form.:
C26H23FN4O4
Mol. Mass.:
474.4836
SMILES:
C[C@H](NC(=O)c1c(nnn1CCOc1ccc(F)cc1)-c1ccccc1)c1ccc(cc1)C(O)=O |r|
Structure:
Search PDB for entries with ligand similarity: