Reaction Details Report a problem with these data
Target
Tubulin beta chain
Ligand
BDBM50520178
Substrate
n/a
Meas. Tech.
ChEMBL_1879190 (CHEMBL4380584)
Kd
2660±n/a nM
Citation
 Chen, H; Deng, S; Wang, Y; Albadari, N; Kumar, G; Ma, D; Li, W; White, SW; Miller, DD; Li, W Structure-Activity Relationship Study of Novel 6-Aryl-2-benzoyl-pyridines as Tubulin Polymerization Inhibitors with Potent Antiproliferative Properties. J Med Chem 63:827-846 (2020) [PubMed]  Article 
Target
Name:
Tubulin beta chain
Synonyms:
Beta-tubulin | TBB_PIG | Tubulin beta chain
Type:
PROTEIN
Mol. Mass.:
49840.26
Organism:
Sus scrofa
Description:
ChEMBL_105107
Residue:
445
Sequence:
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEEGEEDEA
  
Inhibitor
Name:
BDBM50520178
Synonyms:
CHEMBL4468642
Type:
Small organic molecule
Emp. Form.:
C22H21NO5
Mol. Mass.:
379.4058
SMILES:
COc1cc(cc(OC)c1OC)C(=O)c1cccc(n1)-c1ccc(C)c(O)c1
Structure:
Search PDB for entries with ligand similarity: