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Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM50520725
Substrate
n/a
Meas. Tech.
ChEMBL_1881900 (CHEMBL4383399)
EC50
39±n/a nM
Citation
 Yang, X; Shen, J; Jiang, L; Li, W; Yu, M; Pan, G; Yan, Y; Zhang, C; Jia, W; Xiao, L; Yu, H; Chen, H; Zheng, Y; Yu, L; Xie, Q; Zhou, L; Shao, L Discovery, cocrystallization and biological evaluation of novel piperidine derivatives as high affinity Ls-AChBP ligands possessing ?7 nAChR activities. Eur J Med Chem 160:37-48 (2018) [PubMed]  Article 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_HUMAN | CHRNA7 | Cholinergic, Nicotinic Alpha7 | NACHRA7 | Neuronal acetylcholine receptor protein alpha-7 subunit | Neuronal acetylcholine receptor subunit alpha-7 (nAChR-alpha 7) | Nicotinic acetylcholine receptor alpha-7 (alpha7 nAChR)
Type:
n/a
Mol. Mass.:
56448.33
Organism:
Human
Description:
CHRNA7 (NACHRA7)
Residue:
502
Sequence:
MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM50520725
Synonyms:
CHEMBL4532388
Type:
Small organic molecule
Emp. Form.:
C19H22N2O
Mol. Mass.:
294.3908
SMILES:
Cc1ccc(cc1)-c1ccc(O[C@H]2CN3CCC2CC3)cn1 |r,wU:12.12,(68.2,-26.02,;66.86,-25.25,;65.53,-26.02,;64.2,-25.25,;64.2,-23.71,;65.53,-22.94,;66.86,-23.7,;62.87,-22.94,;62.87,-21.39,;61.54,-20.62,;60.22,-21.39,;58.88,-20.62,;57.54,-21.38,;57.54,-22.92,;56.21,-23.68,;54.89,-22.92,;54.89,-21.38,;56.21,-20.6,;57.04,-22.14,;55.82,-22.37,;60.21,-22.93,;61.53,-23.7,)|
Structure:
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