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Target
Prostaglandin G/H synthase 1
Ligand
BDBM50076524
Substrate
n/a
Meas. Tech.
ChEBML_51668
IC50
>1000000±n/a nM
Citation
 Pinto, DJ; Batt, DG; Pitts, WJ; Petraitis, JJ; Orwat, MJ; Wang, S; Jetter, JW; Sherk, SR; Houghton, GC; Copeland, RA; Covington, MB; Trzaskos, JM; Magolda, RL Terphenyl cyclooxygenase-2 (COX-2) inhibitors: optimization of the central ring and o-biphenyl analogs. Bioorg Med Chem Lett 9:919-24 (1999) [PubMed]  Article 
Target
Name:
Prostaglandin G/H synthase 1
Synonyms:
COX1 | Cyclooxygenase-1 | Cyclooxygenase-1 (COX-1) | PGH1_SHEEP | PTGS1 | Prostaglandin G/H synthase (cyclooxygenase)
Type:
Protein
Mol. Mass.:
68868.60
Organism:
Ovis aries (Sheep)
Description:
n/a
Residue:
600
Sequence:
MSRQSISLRFPLLLLLLSPSPVFSADPGAPAPVNPCCYYPCQHQGICVRFGLDRYQCDCTRTGYSGPNCTIPEIWTWLRTTLRPSPSFIHFLLTHGRWLWDFVNATFIRDTLMRLVLTVRSNLIPSPPTYNIAHDYISWESFSNVSYYTRILPSVPRDCPTPMDTKGKKQLPDAEFLSRRFLLRRKFIPDPQSTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQYQLRLFKDGKLKYQMLNGEVYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLYATIWLREHNRVCDLLKAEHPTWGDEQLFQTARLILIGETIKIVIEEYVQQLSGYFLQLKFDPELLFGAQFQYRNRIAMEFNQLYHWHPLMPDSFRVGPQDYSYEQFLFNTSMLVDYGVEALVDAFSRQPAGRIGGGRNIDHHILHVAVDVIKESRVLRLQPFNEYRKRFGMKPYTSFQELTGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEMGAPFSLKGLLGNPICSPEYWKASTFGGEVGFNLVKTATLKKLVCLNTKTCPYVSFHVPDPRQEDRPGVERPPTEL
  
Inhibitor
Name:
BDBM50076524
Synonyms:
4-Methanesulfonyl-[1,1';2',1'']terphenyl | CHEMBL101503
Type:
Small organic molecule
Emp. Form.:
C19H16O2S
Mol. Mass.:
308.394
SMILES:
CS(=O)(=O)c1ccc(cc1)-c1ccccc1-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: