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Target
Kallikrein-5
Ligand
BDBM50522497
Substrate
n/a
Meas. Tech.
ChEMBL_1886792 (CHEMBL4388469)
IC50
251±n/a nM
Citation
 Walker, AL; Bingham, RP; Edgar, EV; Ferrie, A; Holmes, DS; Liddle, J; Polyakova, O; Rella, M; Smith, KJ; Thorpe, JH; Wang, Y; White, GV; Young, RJ; Hovnanian, A Structure guided drug design to develop kallikrein 5 inhibitors to treat Netherton syndrome. Bioorg Med Chem Lett 29:1454-1458 (2019) [PubMed]  Article 
Target
Name:
Kallikrein-5
Synonyms:
KLK5 | KLK5_HUMAN | Kallikrein 5 | SCTE | kallikrein-related peptidase 5 preproprotein
Type:
PROTEIN
Mol. Mass.:
32031.72
Organism:
Homo sapiens (Human)
Description:
EBI_12584
Residue:
293
Sequence:
MATARPPWMWVLCALITALLLGVTEHVLANNDVSCDHPSNTVPSGSNQDLGAGAGEDARSDDSSSRIINGSDCDMHTQPWQAALLLRPNQLYCGAVLVHPQWLLTAAHCRKKVFRVRLGHYSLSPVYESGQQMFQGVKSIPHPGYSHPGHSNDLMLIKLNRRIRPTKDVRPINVSSHCPSAGTKCLVSGWGTTKSPQVHFPKVLQCLNISVLSQKRCEDAYPRQIDDTMFCAGDKAGRDSCQGDSGGPVVCNGSLQGLVSWGDYPCARPNRPGVYTNLCKFTKWIQETIQANS
  
Inhibitor
Name:
BDBM50522497
Synonyms:
CHEMBL4466736
Type:
Small organic molecule
Emp. Form.:
C21H24N6O4
Mol. Mass.:
424.4531
SMILES:
OC=O.CNC(=O)COc1cc(NCc2nc(c[nH]2)-c2ccccc2)ccc1C(N)=N
Structure:
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