Reaction Details Report a problem with these data
Target
Bile acid receptor
Ligand
BDBM50527032
Substrate
n/a
Meas. Tech.
ChEMBL_1901879 (CHEMBL4404101)
EC50
>10000±n/a nM
Citation
Chianelli, D; Rucker, PV; Roland, J; Tully, DC; Nelson, J; Liu, X; Bursulaya, B; Hernandez, ED; Wu, J; Prashad, M; Schlama, T; Liu, Y; Chu, A; Schmeits, J; Huang, DJ; Hill, R; Bao, D; Zoll, J; Kim, Y; Groessl, T; McNamara, P; Liu, B; Richmond, W; Sancho-Martinez, I; Phimister, A; Seidel, HM; Badman, MK; Joseph, SB; Laffitte, B; Molteni, V Nidufexor (LMB763), a Novel FXR Modulator for the Treatment of Nonalcoholic Steatohepatitis. J Med Chem 63:3868-3880 (2020) [PubMed] Article
More Info.:
Target
Name:
Bile acid receptor
Synonyms:
BAR | Bile acid receptor FXR | FXR | Farnesol receptor HRR-1 | HRR1 | NR1H4 | NR1H4_HUMAN | Nuclear receptor subfamily 1 group H member 4 | RIP14 | RXR-interacting protein 14 | Retinoid X receptor-interacting protein 14 | farnesoid x receptor
Type:
Nuclear Receptor
Mol. Mass.:
55916.24
Organism:
Human
Description:
Q96RI1
Residue:
486
Sequence:
MVMQFQGLENPIQISPHCSCTPSGFFMEMMSMKPAKGVLTEQVAGPLGQNLEVEPYSQYSNVQFPQVQPQISSSSYYSNLGFYPQQPEEWYSPGIYELRRMPAETLYQGETEVAEMPVTKKPRMGASAGRIKGDELCVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCVMDMYMRRKCQECRLRKCKEMGMLAECMYTGLLTEIQCKSKRLRKNVKQHADQTVNEDSEGRDLRQVTSTTKSCREKTELTPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLILTEMATNHVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPSGHSDLLEERIRNSGISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDREAVEKLQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELRTFNHHHAEMLMSWRVNDHKFTPLLCEIWDVQ