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Target
Glycogen [starch] synthase, liver
Ligand
BDBM50529620
Substrate
n/a
Meas. Tech.
ChEMBL_1909270 (CHEMBL4411716)
EC50
4100±n/a nM
Citation
 Kasangana, PB; Haddad, PS; Eid, HM; Nachar, A; Stevanovic, T Bioactive Pentacyclic Triterpenes from the Root Bark Extract of Myrianthus arboreus, a Species Used Traditionally to Treat Type-2 Diabetes. J Nat Prod 81:2169-2176 (2018) [PubMed]  Article 
Target
Name:
Glycogen [starch] synthase, liver
Synonyms:
2.4.1.11 | GYS2 | GYS2_HUMAN | Glycogen [starch] synthase, liver
Type:
PROTEIN
Mol. Mass.:
80993.15
Organism:
Homo sapiens
Description:
ChEMBL_118993
Residue:
703
Sequence:
MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN
  
Inhibitor
Name:
BDBM50529620
Synonyms:
CHEMBL4558600
Type:
Small organic molecule
Emp. Form.:
C42H58O9
Mol. Mass.:
706.9045
SMILES:
[H][C@@]12CC[C@]3(C)[C@]([H])(CC=C4[C@]5([H])[C@](C)(O)[C@H](C)CC[C@@]5(CC[C@@]34C)C(O)=O)[C@@]1(C)C[C@@H](OC(C)=O)[C@H](OC(=O)\C=C\c1ccc(O)c(OC)c1)C2(C)C |r,t:9|
Structure:
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