Reaction Details Report a problem with these data
Target
Transthyretin
Ligand
BDBM50240510
Substrate
n/a
Meas. Tech.
ChEMBL_1911555 (CHEMBL4414001)
IC50
12000±n/a nM
Citation
 Yokoyama, T; Mizuguchi, M Crown Ethers as Transthyretin Amyloidogenesis Inhibitors. J Med Chem 62:2076-2082 (2019) [PubMed]  Article 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM50240510
Synonyms:
CHEMBL898 | DIFLUNISAL
Type:
Small organic molecule
Emp. Form.:
C13H8F2O3
Mol. Mass.:
250.1976
SMILES:
OC(=O)c1cc(ccc1O)-c1ccc(F)cc1F
Structure:
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