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Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50085816
Substrate
n/a
Meas. Tech.
ChEMBL_71869 (CHEMBL877834)
Ki
0.32±n/a nM
Citation
 Koerber, SC; Rizo, J; Struthers, RS; Rivier, JE Consensus bioactive conformation of cyclic GnRH antagonists defined by NMR and molecular modeling. J Med Chem 43:819-28 (2000) [PubMed]  Article 
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR | GNRHR_HUMAN | GRHR | GnRH receptor | GnRH-R | Gonadotropin releasing hormone 1 (GnRHR1) | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH)
Type:
Enzyme
Mol. Mass.:
37749.45
Organism:
Human
Description:
P30968
Residue:
328
Sequence:
MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL
  
Inhibitor
Name:
BDBM50085816
Synonyms:
CHEMBL441208 | dicyclo(4-10/5-8)[Ac-D2Nal-DCpa-DTrp-Asp-Glu-DArg-Leu-Lys-Pro-Dpr-NH2]
Type:
Small organic molecule
Emp. Form.:
C70H90ClN17O13
Mol. Mass.:
1413.023
SMILES:
CC(C)C[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCC(=O)NCCCC[C@@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CNC(=O)C[C@H](NC(=O)[C@@H](Cc1c[nH]c3ccccc13)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc3ccccc3c1)NC(C)=O)C(=O)N2)C(N)=O
Structure:
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