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Target
Tyrosine-protein kinase SYK
Ligand
BDBM50535113
Substrate
n/a
Meas. Tech.
ChEMBL_1929867 (CHEMBL4433043)
IC50
158±n/a nM
Citation
 Garton, NS; Barker, MD; Davis, RP; Douault, C; Hooper-Greenhill, E; Jones, E; Lewis, HD; Liddle, J; Lugo, D; McCleary, S; Preston, AGS; Ramirez-Molina, C; Neu, M; Shipley, TJ; Somers, DO; Watson, RJ; Wilson, DM Optimisation of a novel series of potent and orally bioavailable azanaphthyridine SYK inhibitors. Bioorg Med Chem Lett 26:4606-4612 (2016) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase SYK
Synonyms:
KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk)
Type:
Enzyme
Mol. Mass.:
72079.99
Organism:
Homo sapiens (Human)
Description:
P43405
Residue:
635
Sequence:
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
  
Inhibitor
Name:
BDBM50535113
Synonyms:
CHEMBL4473150
Type:
Small organic molecule
Emp. Form.:
C17H18F2N6O
Mol. Mass.:
360.3612
SMILES:
Cn1cc(cn1)-c1cc2nccnc2c(OCC2CNCC(F)(F)C2)n1
Structure:
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