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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50541797
Substrate
n/a
Meas. Tech.
ChEMBL_1985369 (CHEMBL4618775)
Kd
112000±n/a nM
Citation
 Nichols, C; Ng, J; Keshu, A; Kelly, G; Conte, MR; Marber, MS; Fraternali, F; De Nicola, GF Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1?-IL1R and p38?-TAB1 Complexes. J Med Chem 63:7559-7568 (2020) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
Crk1 | Csbp1 | Csbp2 | MAP Kinase p38 alpha | MAP kinase p38 | MK14_MOUSE | Mapk14 | Mitogen-activated protein kinase 14 | Mitogen-activated protein kinase p38 alpha
Type:
Enzyme
Mol. Mass.:
41281.22
Organism:
Mus musculus (mouse)
Description:
The full-length open reading frame of murine p38 alpha was cloned and expressed in E. coli.. Soluble murine p38R was extracted from cell pellets and purified using ion-exchange chromatography.
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50541797
Synonyms:
CHEMBL4646170
Type:
Small organic molecule
Emp. Form.:
C12H21N3
Mol. Mass.:
207.3152
SMILES:
NC(=N)NCC12CC3CC(CC(C3)C1)C2 |THB:13:5:8:11.12.10,13:11:8:6.14.5,10:9:6:13.11.12,10:11:6:8.9.14|
Structure:
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