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Target
Sodium-dependent serotonin transporter
Ligand
BDBM50102019
Substrate
n/a
Meas. Tech.
ChEBML_201982
Ki
10±n/a nM
Citation
 Meagher, KL; Mewshaw, RE; Evrard, DA; Zhou, P; Smith, DL; Scerni, R; Spangler, T; Abulhawa, S; Shi, X; Schechter, LE; Andree, TH Studies towards the next generation of antidepressants. Part 1: Indolylcyclohexylamines as potent serotonin reuptake inhibitors. Bioorg Med Chem Lett 11:1885-8 (2001) [PubMed]  Article 
Target
Name:
Sodium-dependent serotonin transporter
Synonyms:
5-HT Transporter | 5-HTT | 5HT transporter | 5HTT | Anandamid membrane transporter, AMT | Anandamide membrane transporter, AMT | Monoamine transporters; Norepinephrine & serotonin | SC6A4_RAT | Slc6a4 | Sodium-dependent serotonin transporter | Sodium-dependent serotonin transporter (SERT) | imipramine receptor
Type:
Multi-pass membrane protein
Mol. Mass.:
70168.43
Organism:
Rat
Description:
P31652
Residue:
630
Sequence:
METTPLNSQKVLSECKDREDCQENGVLQKGVPTTADRAEPSQISNGYSAVPSTSAGDEASHSIPAATTTLVAEIRQGERETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIIAWALYYLISSLTDRLPWTSCTNSWNTGNCTNYFAQDNITWTLHSTSPAEEFYLRHVLQIHQSKGLQDLGTISWQLTLCIVLIFTVIYFSIWKGVKTSGKVVWVTATFPYIVLSVLLVRGATLPGAWRGVVFYLKPNWQKLLETGVWVDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWAKRREWFVLIVVITCVLGSLLTLTSGGAYVVTLLEEYATGPAVLTVALIEAVAVSWFYGITQFCSDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPHWSIVLGYCIGMSSVICIPTYIIYRLISTPGTLKERIIKSITPETPTEIPCGDIRMNAV
  
Inhibitor
Name:
BDBM50102019
Synonyms:
3-[4-(3,4-Dihydro-1H-isoquinolin-2-yl)-cyclohexyl]-1H-indole-5-carbonitrile | CHEMBL55505 | trans-3-(4-(3,4-dihydroisoquinolin-2(1H)-yl)cyclohexyl)-1H-indole-5-carbonitrile
Type:
Small organic molecule
Emp. Form.:
C24H25N3
Mol. Mass.:
355.4754
SMILES:
N#Cc1ccc2[nH]cc([C@H]3CC[C@@H](CC3)N3CCc4ccccc4C3)c2c1 |r,wU:9.8,wD:12.15,(14.62,-2.1,;15.1,-3.56,;15.58,-5.02,;14.55,-6.17,;15.04,-7.64,;16.54,-7.95,;17.32,-9.29,;18.84,-8.96,;19,-7.42,;20.33,-6.64,;20.32,-5.11,;21.65,-4.34,;22.99,-5.11,;22.99,-6.65,;21.66,-7.42,;24.32,-4.34,;24.32,-2.8,;25.66,-2.04,;26.99,-2.81,;28.32,-2.05,;29.64,-2.82,;29.64,-4.36,;28.31,-5.12,;26.98,-4.35,;25.66,-5.11,;17.58,-6.79,;17.09,-5.33,)|
Structure:
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