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Target
RNA-directed RNA polymerase
Ligand
BDBM50545010
Substrate
n/a
Meas. Tech.
ChEMBL_1994246 (CHEMBL4628141)
EC50
0.800000±n/a nM
Citation
 Xiao, D; Dai, X; Liu, H; He, S; Shi, ZC; Ludmerer, SW; Li, F; Nargund, R; Palani, A Multi-step parallel synthesis enabled optimization of benzofuran derivatives as pan-genotypic non-nucleoside inhibitors of HCV NS5B. Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article 
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
  
Inhibitor
Name:
BDBM50545010
Synonyms:
CHEMBL4641600
Type:
Small organic molecule
Emp. Form.:
C34H27F3N4O5S
Mol. Mass.:
660.662
SMILES:
CNC(=O)c1c(oc2cc(N(C)S(C)(=O)=O)c(cc12)-c1ccc2nc(C)n(Cc3ccc(F)cc3F)c(=O)c2c1)-c1ccc(F)cc1
Structure:
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