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Target
Tubulin alpha-1A chain
Ligand
BDBM50103820
Substrate
n/a
Meas. Tech.
ChEBML_211858
IC50
1000±n/a nM
Citation
 Flynn, BL; Flynn, GP; Hamel, E; Jung, MK The synthesis and tubulin binding activity of thiophene-based analogues of combretastatin A-4. Bioorg Med Chem Lett 11:2341-3 (2001) [PubMed]  Article 
Target
Name:
Tubulin alpha-1A chain
Synonyms:
TBA1A_PIG | TUBA1A | Tubulin | Tubulin alpha chain | Tubulin alpha-1A chain
Type:
Protein
Mol. Mass.:
50049.25
Organism:
Pig
Description:
P02550
Residue:
451
Sequence:
MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFSVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRAHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYEPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGVDSVEGEGEEEGEEY
  
Inhibitor
Name:
BDBM50103820
Synonyms:
CHEMBL309058 | [2-(3-Hydroxy-4-methoxy-phenyl)-thiophen-3-yl]-(3,4,5-trimethoxy-phenyl)-methanone
Type:
Small organic molecule
Emp. Form.:
C21H20O6S
Mol. Mass.:
400.445
SMILES:
COc1ccc(cc1O)-c1sccc1C(=O)c1cc(OC)c(OC)c(OC)c1
Structure:
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