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Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50105861
Substrate
n/a
Meas. Tech.
ChEMBL_71732 (CHEMBL680411)
IC50
0.09±n/a nM
Citation
 Rahimipour, S; Ben-Aroya, N; Fridkin, M; Koch, Y Design, synthesis, and evaluation of a long-acting, potent analogue of gonadotropin-releasing hormone. J Med Chem 44:3645-52 (2001) [PubMed]  Article 
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR_RAT | GnRH receptor | GnRH-R | Gnrhr
Type:
PROTEIN
Mol. Mass.:
37767.60
Organism:
Rattus norvegicus
Description:
ChEMBL_1335047
Residue:
327
Sequence:
MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL
  
Inhibitor
Name:
BDBM50105861
Synonyms:
CHEMBL414239 | pGlu-His-Trp-Ser-Tyr-D-Lys(N-(2 chloro-1,4-naphthoquinonyl)-beta-alanine)-Leu-Arg-Pro-Gly-NH2([D-Lys6NQ])GnRH)
Type:
Small organic molecule
Emp. Form.:
C72H92ClN19O17
Mol. Mass.:
1531.071
SMILES:
CC(C)C[C@H](NC(=O)[C@H](CCCCNC(=O)CC=Nc1c(O)c2ccccc2c(O)c1Cl)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NOC(=O)C1CCC(=O)N1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O |w:17.16|
Structure:
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