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Target
Tyrosine-protein kinase Lyn
Ligand
BDBM100152
Substrate
n/a
Meas. Tech.
ChEBML_221498
IC50
>250000±n/a nM
Citation
 Song, Y; Wang, J; Teng, SF; Kesuma, D; Deng, Y; Duan, J; Wang, JH; Qi, RZ; Sim, MM Beta-carbolines as specific inhibitors of cyclin-dependent kinases. Bioorg Med Chem Lett 12:1129-32 (2002) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase Lyn
Synonyms:
JTK8 | LYN | LYN_HUMAN | Lck/Yes-related novel protein tyrosine kinase | Tyrosine-protein kinase Lyn (LYN) | V-yes-1 Yamaguchi sarcoma viral related oncogene homolog | p53Lyn | p56Lyn
Type:
Protein
Mol. Mass.:
58575.92
Organism:
Homo sapiens (Human)
Description:
P07948
Residue:
512
Sequence:
MGCIKSKGKDSLSDDGVDLKTQPVRNTERTIYVRDPTSNKQQRPVPESQLLPGQRFQTKDPEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAKLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFYTATEGQYQQQP
  
Inhibitor
Name:
BDBM100152
Synonyms:
7-methoxy-1-methyl-9H-beta-carboline;hydrochloride | 7-methoxy-1-methyl-9H-pyrido[3,4-b]indole;hydrochloride | HARMINE | Harmine hydrochloride | MLS002153910 | SMR001233259 | cid_5359389
Type:
Small organic molecule
Emp. Form.:
C13H12N2O
Mol. Mass.:
212.2472
SMILES:
COc1ccc2c(c1)[nH]c1c(C)nccc21
Structure:
Search PDB for entries with ligand similarity: