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Target
CD40 ligand
Ligand
BDBM50552391
Substrate
n/a
Meas. Tech.
ChEMBL_2034160 (CHEMBL4688318)
IC50
>10000±n/a nM
Citation
 Xiao, HY; Li, N; Duan, JJ; Jiang, B; Lu, Z; Ngu, K; Tino, J; Kopcho, LM; Lu, H; Chen, J; Tebben, AJ; Sheriff, S; Chang, CY; Yanchunas, J; Calambur, D; Gao, M; Shuster, DJ; Susulic, V; Xie, JH; Guarino, VR; Wu, DR; Gregor, KR; Goldstine, CB; Hynes, J; Macor, JE; Salter-Cid, L; Burke, JR; Shaw, PJ; Dhar, TGM Biologic-like In Vivo Efficacy with Small Molecule Inhibitors of TNF? Identified Using Scaffold Hopping and Structure-Based Drug Design Approaches. J Med Chem 63:15050-15071 (2020) [PubMed]  Article 
Target
Name:
CD40 ligand
Synonyms:
CD40 ligand | CD40 ligand, membrane form | CD40 ligand, soluble form | CD40-L | CD40L | CD40LG | CD40L_HUMAN | CD_antigen=CD154 | T-cell antigen Gp39 | TNF-related activation protein | TNFSF5 | TRAP | sCD40L
Type:
PROTEIN
Mol. Mass.:
29279.25
Organism:
Homo sapiens
Description:
ChEMBL_117692
Residue:
261
Sequence:
MIETYNQTSPRSAATGLPISMKIFMYLLTVFLITQMIGSALFAVYLHRRLDKIEDERNLHEDFVFMKTIQRCNTGERSLSLLNCEEIKSQFEGFVKDIMLNKEETKKENSFEMQKGDQNPQIAAHVISEASSKTTSVLQWAEKGYYTMSNNLVTLENGKQLTVKRQGLYYIYAQVTFCSNREASSQAPFIASLCLKSPGRFERILLRAANTHSSAKPCGQQSIHLGGVFELQPGASVFVNVTDPSQVSHGTGFTSFGLLKL
  
Inhibitor
Name:
BDBM50552391
Synonyms:
CHEMBL4777447
Type:
Small organic molecule
Emp. Form.:
C25H21ClF2N6O
Mol. Mass.:
494.924
SMILES:
C[C@@H](Nc1c(Cl)c(C)nc2cc(F)c(nc12)-c1cnc(nc1)C(C)(C)O)c1cc(ccc1F)C#N |r|
Structure:
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