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Target
Nitric oxide synthase, inducible
Ligand
BDBM50115777
Substrate
n/a
Meas. Tech.
ChEMBL_89349 (CHEMBL699680)
IC50
30±n/a nM
Citation
 Rojas, J; Payá, M; Dominguez, JN; Luisa Ferrándiz, M The synthesis and effect of fluorinated chalcone derivatives on nitric oxide production. Bioorg Med Chem Lett 12:1951-4 (2002) [PubMed]  Article 
Target
Name:
Nitric oxide synthase, inducible
Synonyms:
Inducible NO synthase | Inducible NOS | Inducible nitric oxide synthase (iNOS) | Inosl | MAC-NOS | Macrophage NOS | NOS type II | NOS2_MOUSE | Nitric Oxide Synthase, inducible | Nitric oxide synthase, inducible (iNOS) | Nos2
Type:
Enzyme
Mol. Mass.:
130595.79
Organism:
Mus musculus (mouse)
Description:
Recombinant enzyme overexpressed in E. coli.
Residue:
1144
Sequence:
MACPWKFLFKVKSYQSDLKEEKDINNNVKKTPCAVLSPTIQDDPKSHQNGSPQLLTGTAQNVPESLDKLHVTSTRPQYVRIKNWGSGEILHDTLHHKATSDFTCKSKSCLGSIMNPKSLTRGPRDKPTPLEELLPHAIEFINQYYGSFKEAKIEEHLARLEAVTKEIETTGTYQLTLDELIFATKMAWRNAPRCIGRIQWSNLQVFDARNCSTAQEMFQHICRHILYATNNGNIRSAITVFPQRSDGKHDFRLWNSQLIRYAGYQMPDGTIRGDAATLEFTQLCIDLGWKPRYGRFDVLPLVLQADGQDPEVFEIPPDLVLEVTMEHPKYEWFQELGLKWYALPAVANMLLEVGGLEFPACPFNGWYMGTEIGVRDFCDTQRYNILEEVGRRMGLETHTLASLWKDRAVTEINVAVLHSFQKQNVTIMDHHTASESFMKHMQNEYRARGGCPADWIWLVPPVSGSITPVFHQEMLNYVLSPFYYYQIEPWKTHIWQNEKLRPRRREIRFRVLVKVVFFASMLMRKVMASRVRATVLFATETGKSEALARDLATLFSYAFNTKVVCMDQYKASTLEEEQLLLVVTSTFGNGDCPSNGQTLKKSLFMLRELNHTFRYAVFGLGSSMYPQFCAFAHDIDQKLSHLGASQLAPTGEGDELSGQEDAFRSWAVQTFRAACETFDVRSKHHIQIPKRFTSNATWEPQQYRLIQSPEPLDLNRALSSIHAKNVFTMRLKSQQNLQSEKSSRTTLLVQLTFEGSRGPSYLPGEHLGIFPGNQTALVQGILERVVDCPTPHQTVCLEVLDESGSYWVKDKRLPPCSLSQALTYFLDITTPPTQLQLHKLARFATDETDRQRLEALCQPSEYNDWKFSNNPTFLEVLEEFPSLHVPAAFLLSQLPILKPRYYSISSSQDHTPSEVHLTVAVVTYRTRDGQGPLHHGVCSTWIRNLKPQDPVPCFVRSVSGFQLPEDPSQPCILIGPGTGIAPFRSFWQQRLHDSQHKGLKGGRMSLVFGCRHPEEDHLYQEEMQEMVRKRVLFQVHTGYSRLPGKPKVYVQDILQKQLANEVLSVLHGEQGHLYICGDVRMARDVATTLKKLVATKLNLSEEQVEDYFFQLKSQKRYHEDIFGAVFSYGAKKGSALEEPKATRL
  
Inhibitor
Name:
BDBM50115777
Synonyms:
(E)-1-(4'-Fluorophenyl)-3-(3'',4'',5''-trimethoxyphenyl)prop-2-en-1-one | 3-(3-Ethoxy-4,5-dimethoxy-phenyl)-1-(4-fluoro-phenyl)-propenone | CHEMBL59026
Type:
Small organic molecule
Emp. Form.:
C18H17FO4
Mol. Mass.:
316.3236
SMILES:
COc1cc(\C=C\C(=O)c2ccc(F)cc2)cc(OC)c1OC
Structure:
Search PDB for entries with ligand similarity: