Reaction Details
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Target
Neprilysin
Ligand
BDBM50115847
Substrate
n/a
Meas. Tech.
ChEBML_144469
Ki
13±n/a nM
Citation
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More Info.:
Target
Name:
Neprilysin
Synonyms:
Atriopeptidase | CD10 antigen | CD_antigen=CD10 | Enkephalinase | MME | NEP | NEP_RABIT | Neutral Endopeptidase | Neutral endopeptidase 24.11
Type:
Enzyme
Mol. Mass.:
85570.75
Organism:
Oryctolagus cuniculus (rabbit)
Description:
NEP was purified to homogeneity from rabbit kidney.
Residue:
750
Sequence:
MGRSESQMDITDINTPKPKKKQRWTPLEISLSVLVLLLTVIAVTMIALYATYDDGICKSSDCIKSAARLIQNMDATAEPCTDFFKYACGGWLKRNVIPETSSRYSNFDILRDELEVILKDVLQEPKTEDIVAVQKAKTLYRSCVNETAIDSRGGQPLLKLLPDVYGWPVATQNWEQTYGTSWSAEKSIAQLNSNYGKKVLINFFVGTDDKNSMNHIIHIDQPRLGLPSRDYYECTGIYKEACTAYVDFMIAVAKLIRQEEGLPIDENQISVEMNKVMELEKEIANATTKSEDRNDPMLLYNKMTLAQIQNNFSLEINGKPFSWSNFTNEIMSTVNINIPNEEDVVVYAPEYLIKLKPILTKYFPRDFQNLFSWRFIMDLVSSLSRTYKDSRNAFRKALYGTTSESATWRRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKKAEEKALAIKERIGYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWITGAAIVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSANNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGIGQAYRAYQNYVKKNGEEKLLPGIDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGSLQNSVEFSEAFQCPKNSYMNPEKKCRVW
Inhibitor
Name:
BDBM50115847
Synonyms:
(2S)-2-[(2R)-2-[(1S)-5-bromo-2,3-dihydro-1H-inden-1-yl]-3-sulfanylpropanamido]-3-(1H-indol-3-yl)propanoic acid | CHEMBL293685
Type:
Small organic molecule
Emp. Form.:
C23H23BrN2O3S
Mol. Mass.:
487.409
SMILES:
OC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CS)[C@@H]1CCc2cc(Br)ccc12