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Target
5-hydroxytryptamine receptor 6
Ligand
BDBM50007677
Substrate
n/a
Meas. Tech.
ChEMBL_2058200 (CHEMBL4713201)
Ki
>10000±n/a nM
Citation
 Bechthold, E; Schreiber, JA; Lehmkuhl, K; Frehland, B; Schepmann, D; Bernal, FA; Daniliuc, C; Álvarez, I; Garcia, CV; Schmidt, TJ; Seebohm, G; Wünsch, B Ifenprodil Stereoisomers: Synthesis, Absolute Configuration, and Correlation with Biological Activity. J Med Chem 64:1170-1179 (2021) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 6
Synonyms:
5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46968.43
Organism:
Human
Description:
P50406
Residue:
440
Sequence:
MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
  
Inhibitor
Name:
BDBM50007677
Synonyms:
(+)-threo 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydroxy-propyl]-phenol | (-)-threo 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydroxy-propyl]-phenol | 4-[(1S,2S)-2-(4-Benzyl-piperidin-1-yl)-1-hydroxy-propyl]-phenol | 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydroxy-propyl]-phenol | CHEMBL319706 | Ifenprodil
Type:
Small organic molecule
Emp. Form.:
C21H27NO2
Mol. Mass.:
325.4446
SMILES:
C[C@@H]([C@@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1
Structure:
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