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Mitogen-activated protein kinase kinase kinase 7
Ligand
BDBM50557650
Substrate
n/a
Meas. Tech.
ChEMBL_2059732 (CHEMBL4714733)
Kd
55±n/a nM
Citation
Veerman, JJN; Bruseker, YB; Damen, E; Heijne, EH; van Bruggen, W; Hekking, KFW; Winkel, R; Hupp, CD; Keefe, AD; Liu, J; Thomson, HA; Zhang, Y; Cuozzo, JW; McRiner, AJ; Mulvihill, MJ; van Rijnsbergen, P; Zech, B; Renzetti, LM; Babiss, L; Müller, G Discovery of 2,4-1 ACS Med Chem Lett 12:555-562 (2021) [PubMed] Article More Info.:
Target
Name:
Mitogen-activated protein kinase kinase kinase 7
Synonyms:
M3K7_HUMAN | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7 | TAK1 | TAK1/TAB1 | TGF-beta-activated kinase 1 | Transforming growth factor-beta-activated kinase 1 (TAK1)
Type:
Protein
Mol. Mass.:
67199.89
Organism:
Homo sapiens (Human)
Description:
O43318
Residue:
606
Sequence:
MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQSESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIAATTAYSKPKRGHRKTASFGNILDVPEIVISGNGQPRRRSIQDLTVTGTEPGQVSSRSSSPSVRMITTSGPTSEKPTRSHPWTPDDSTDTNGSDNSIPMAYLTLDHQLQPLAPCPNSKESMAVFEQHCKMAQEYMKVQTEIALLLQRKQELVAELDQDEKDQQNTSRLVQEHKKLLDENKSLSTYYQQCKKQLEVIRSQQQKRQGTS
Inhibitor
Name:
BDBM50557650
Synonyms:
CHEMBL4779479
Type:
Small organic molecule
Emp. Form.:
C20H23F2N5O4
Mol. Mass.:
435.4245
SMILES:
CNC(=O)CN(Cc1ccccc1OC(F)F)C(=O)c1c[nH]c(n1)C(=O)N1CCCC1
Structure:
