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Target
Potassium channel subfamily T member 1
Ligand
BDBM50557659
Substrate
n/a
Meas. Tech.
ChEMBL_2059777 (CHEMBL4714778)
IC50
977±n/a nM
Citation
 Griffin, AM; Kahlig, KM; Hatch, RJ; Hughes, ZA; Chapman, ML; Antonio, B; Marron, BE; Wittmann, M; Martinez-Botella, G Discovery of the First Orally Available, Selective K ACS Med Chem Lett 12:593-602 (2021) [PubMed]  Article 
Target
Name:
Potassium channel subfamily T member 1
Synonyms:
KCNT1 | KCNT1_HUMAN | KCa4.1 | KIAA1422 | Potassium channel subfamily T member 1
Type:
PROTEIN
Mol. Mass.:
138357.73
Organism:
Homo sapiens
Description:
ChEMBL_120153
Residue:
1230
Sequence:
MARAKLPRSPSEGKAGPGGAPAGAAAPEEPHGLSPLLPARGGGSVGSDVGQRLPVEDFSLDSSLSQVQVEFYVNENTFKERLKLFFIKNQRSSLRIRLFNFSLKLLTCLLYIVRVLLDDPALGIGCWGCPKQNYSFNDSSSEINWAPILWVERKMTLWAIQVIVAIISFLETMLLIYLSYKGNIWEQIFRVSFVLEMINTLPFIITIFWPPLRNLFIPVFLNCWLAKHALENMINDFHRAILRTQSAMFNQVLILFCTLLCLVFTGTCGIQHLERAGENLSLLTSFYFCIVTFSTVGYGDVTPKIWPSQLLVVIMICVALVVLPLQFEELVYLWMERQKSGGNYSRHRAQTEKHVVLCVSSLKIDLLMDFLNEFYAHPRLQDYYVVILCPTEMDVQVRRVLQIPLWSQRVIYLQGSALKDQDLMRAKMDNGEACFILSSRNEVDRTAADHQTILRAWAVKDFAPNCPLYVQILKPENKFHVKFADHVVCEEECKYAMLALNCICPATSTLITLLVHTSRGQEGQESPEQWQRMYGRCSGNEVYHIRMGDSKFFREYEGKSFTYAAFHAHKKYGVCLIGLKREDNKSILLNPGPRHILAASDTCFYINITKEENSAFIFKQEEKRKKRAFSGQGLHEGPARLPVHSIIASMGTVAMDLQGTEHRPTQSGGGGGGSKLALPTENGSGSRRPSIAPVLELADSSALLPCDLLSDQSEDEVTPSDDEGLSVVEYVKGYPPNSPYIGSSPTLCHLLPVKAPFCCLRLDKGCKHNSYEDAKAYGFKNKLIIVSAETAGNGLYNFIVPLRAYYRSRKELNPIVLLLDNKPDHHFLEAICCFPMVYYMEGSVDNLDSLLQCGIIYADNLVVVDKESTMSAEEDYMADAKTIVNVQTMFRLFPSLSITTELTHPSNMRFMQFRAKDSYSLALSKLEKRERENGSNLAFMFRLPFAAGRVFSISMLDTLLYQSFVKDYMITITRLLLGLDTTPGSGYLCAMKITEGDLWIRTYGRLFQKLCSSSAEIPIGIYRTESHVFSTSESQISVNVEDCEDTREVKGPWGSRAGTGGSSQGRHTGGGDPAEHPLLRRKSLQWARRLSRKAPKQAGRAAAAEWISQQRLSLYRRSERQELSELVKNRMKHLGLPTTGYEDVANLTASDVMNRVNLGYLQDEMNDHQNTLSYVLINPPPDTRLEPSDIVYLIRSDPLAHVASSSQSRKSSCSHKLSSCNPETRDETQL
  
Inhibitor
Name:
BDBM50557659
Synonyms:
CHEMBL4779088
Type:
Small organic molecule
Emp. Form.:
C17H16F3N5O2
Mol. Mass.:
379.3364
SMILES:
CC(NC(=O)c1cc(nn1C)C(F)(F)F)c1noc(n1)-c1cccc(C)c1
Structure:
Search PDB for entries with ligand similarity: