Reaction Details Report a problem with these data
Target
Sigma intracellular receptor 2
Ligand
BDBM50559181
Substrate
n/a
Meas. Tech.
ChEMBL_2068289 (CHEMBL4723542)
Ki
>854±n/a nM
Citation
 Ye, N; Qin, W; Tian, S; Xu, Q; Wold, EA; Zhou, J; Zhen, XC Small Molecules Selectively Targeting Sigma-1 Receptor for the Treatment of Neurological Diseases. J Med Chem 63:15187-15217 (2020) [PubMed]  Article 
Target
Name:
Sigma intracellular receptor 2
Synonyms:
S2r | SGMR2_RAT | Sigma intracellular receptor 2 | Sigma-2 receptor | Sigma2 receptor | Tmem97 | Transmembrane protein 97
Type:
Protein
Mol. Mass.:
20953.88
Organism:
Rattus norvegicus (Rat)
Description:
Q5U3Y7
Residue:
176
Sequence:
MGAVTARRCVEWLLGLYFVSHIPITMFIDLQALLPPELYPQEFSNLLRWYSKEFKDPLMQEPPVWFKSFLFCELVFQLPFFPIAAYAFFKGSCRWIRIPAIIYAVHTITTLIPILYTILFEDFSKAIAFKGQRPENFRERLTLVGVYAPYLIIPLILLLFMLRNPYYKFEEKRKKK
  
Inhibitor
Name:
BDBM50559181
Synonyms:
CHEMBL4760729
Type:
Small organic molecule
Emp. Form.:
C26H27Br2FN2
Mol. Mass.:
546.312
SMILES:
Fc1ccc(cc1)C(NCc1cccc(Br)c1)C1CCN(Cc2ccc(Br)cc2)CC1
Structure:
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