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Target
Serine/threonine-protein kinase pim-3
Ligand
BDBM50559296
Substrate
n/a
Meas. Tech.
ChEMBL_2068632 (CHEMBL4723885)
Ki
<3.0±n/a nM
Citation
 Han, W; Ding, Y; Chen, Z; Langowski, JL; Bellamacina, C; Rico, A; Nishiguchi, GA; Lan, J; Atallah, G; Lindvall, M; Lin, S; Zang, R; Feucht, P; Zavorotinskaya, T; Dai, Y; Garcia, P; Burger, MT Synthesis and Structure-Activity Relationship of Tetra-Substituted Cyclohexyl Diol Inhibitors of Proviral Insertion of Moloney Virus (PIM) Kinases. J Med Chem 63:14885-14904 (2020) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-3
Synonyms:
PIM3 | PIM3_HUMAN | Serine/threonine-protein kinase pim-3 (PIM3)
Type:
Protein
Mol. Mass.:
35888.19
Organism:
Homo sapiens (Human)
Description:
Q86V86
Residue:
326
Sequence:
MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGVPESCDLRLCTLDPDDVASTTSSSESL
  
Inhibitor
Name:
BDBM50559296
Synonyms:
CHEMBL4781892
Type:
Small organic molecule
Emp. Form.:
C24H24F3N5O3
Mol. Mass.:
487.4743
SMILES:
C[C@H]1C[C@H](C[C@@H](O)[C@@]1(O)CF)c1ccncc1NC(=O)c1nc(ncc1N)-c1c(F)cccc1F |r|
Structure:
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