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Target
ATP-dependent 6-phosphofructokinase, liver type
Ligand
BDBM50560998
Substrate
n/a
Meas. Tech.
ChEMBL_2074100 (CHEMBL4729634)
EC50
>100000±n/a nM
Citation
 Zhou, J; Bie, J; Wang, X; Liu, Q; Li, R; Chen, H; Hu, J; Cao, H; Ji, W; Li, Y; Liu, S; Shen, Z; Xu, B Discovery of  J Med Chem 63:10307-10329 (2020) [PubMed]  Article 
Target
Name:
ATP-dependent 6-phosphofructokinase, liver type
Synonyms:
2.7.1.11 | 6-phosphofructokinase type B | ATP-PFK | ATP-dependent 6-phosphofructokinase, liver type | PFK-B | PFKAL_RAT | Pfk-l | Pfkl | Phosphofructo-1-kinase isozyme B | Phosphohexokinase
Type:
PROTEIN
Mol. Mass.:
85347.47
Organism:
Rattus norvegicus
Description:
ChEMBL_120183
Residue:
780
Sequence:
MATVDLEKLRMSGAGKAIGVLTSGGDAQGMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVEGGENIKPANWLSVSNIIQLGGTIIGSARCKAFTTREGRLAAAYNLLQHGITNLCVIGGDGSLTGANIFRNEWGSLLEELVKEGKISESTAQNYAHLSIAGLVGSIDNDFCGTDMTIGTDSALHRIMEVIDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEDGWENFMCERLGETRSRGSRLNIIIIAEGAIDRHGKPISSSYVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRVLSSKMGMEAVMALLEATPDTPACVVSLSGNQSVRLPLMECVQVTKDVQKAMDEKRFDEAIQLRGRSFENNWKIYKLLAHQKVSKEKSNFSLAILNVGAPAAGMNAAVRSAVRTGISEGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKRTLPKPHLEAIVENLRTYNIHALLVIGGFEAYEGVLQLVEARGRYEELCIVMCVIPATISNNVPGTDFSLGSDTAVNAAMESCDRIKQSASGTKRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFNIHDLKANVEHMTEKMKTDIQRGLVLRNEKCHEHYTTEFLYNLYSSEGRGVFDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKAMLWMSEKLRDVYRKGRVFANAPDSACVIGLRKKVVAFSSVTELKKETDFEHRMPREQWWLNLRLMLKMLAHYRISMADYVSGELEHVTRRTLSIDKGF
  
Inhibitor
Name:
BDBM50560998
Synonyms:
CHEMBL4759496
Type:
Small organic molecule
Emp. Form.:
C24H21ClN3NaO5S
Mol. Mass.:
521.948
SMILES:
[Na;v0+].[#6]-[#8]-c1ccc(cc1)S(=O)(=O)[#7-]-[#6](=O)-c1cc2c(-[#7]-c3cccc(-[#8]-[#6])c3)ccc(Cl)c2n1-[#6]
Structure:
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