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Target
Potassium voltage-gated channel subfamily A member 3
Ligand
BDBM50125509
Substrate
n/a
Meas. Tech.
ChEBML_214953
IC50
45±n/a nM
Citation
 Miao, S; Bao, J; Garcia, ML; Goulet, JL; Hong, XJ; Kaczorowski, GJ; Kayser, F; Koo, GC; Kotliar, A; Schmalhofer, WA; Shah, K; Sinclair, PJ; Slaughter, RS; Springer, MS; Staruch, MJ; Tsou, NN; Wong, F; Parsons, WH; Rupprecht, KM Benzamide derivatives as blockers of Kv1.3 ion channel. Bioorg Med Chem Lett 13:1161-4 (2003) [PubMed]  Article 
Target
Name:
Potassium voltage-gated channel subfamily A member 3
Synonyms:
HGK5 | HLK3 | HPCN3 | HuKIII | KCNA3 | KCNA3_HUMAN | Potassium voltage-gated channel subfamily A member 3 | Voltage-gated potassium channel | Voltage-gated potassium channel subunit Kv1.3
Type:
PROTEIN
Mol. Mass.:
63835.47
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1513935
Residue:
575
Sequence:
MDERLSLLRSPPPPSARHRAHPPQRPASSGGAHTLVNHGYAEPAAGRELPPDMTVVPGDHLLEPEVADGGGAPPQGGCGGGGCDRYEPLPPSLPAAGEQDCCGERVVINISGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIFSEEIRFYQLGEEAMEKFREDEGFLREEERPLPRRDFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPEFRDEKDYPASTSQDSFEAAGNSTSGSRAGASSFSDPFFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQGNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADDPTSGFSSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQSQYMHVGSCQHLSSSAEELRKARSNSTLSKSEYMVIEEGGMNHSAFPQTPFKTGNSTATCTTNNNPNSCVNIKKIFTDV
  
Inhibitor
Name:
BDBM50125509
Synonyms:
Allyl-carbamic acid 4-[(5-fluoro-2-methoxy-benzoylamino)-methyl]-4-phenyl-cyclohexyl ester | CHEMBL275152
Type:
Small organic molecule
Emp. Form.:
C25H29FN2O4
Mol. Mass.:
440.5072
SMILES:
COc1ccc(F)cc1C(=O)NC[C@]1(CC[C@@H](CC1)OC(=O)NCC=C)c1ccccc1 |wU:13.13,wD:16.20,(2.06,.16,;3.38,-.59,;3.38,-2.14,;4.71,-2.91,;4.71,-4.45,;3.38,-5.22,;3.36,-6.76,;2.05,-4.45,;2.05,-2.91,;.71,-2.14,;.71,-.59,;-.62,-2.91,;-1.95,-2.14,;-3.28,-2.91,;-1.95,-3.68,;-1.95,-5.22,;-3.28,-5.99,;-4.61,-5.22,;-4.61,-3.68,;-3.28,-7.53,;-1.96,-8.3,;-.63,-7.53,;-1.96,-9.83,;-3.28,-10.6,;-4.62,-9.83,;-5.95,-10.6,;-4.39,-1.82,;-5.84,-2.22,;-6.93,-1.15,;-6.53,.32,;-5.09,.74,;-4,-.33,)|
Structure:
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