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Target
RNA-directed RNA polymerase
Ligand
BDBM50126676
Substrate
n/a
Meas. Tech.
ChEMBL_163994 (CHEMBL766521)
IC50
620±n/a nM
Citation
Chan, L; Reddy, TJ; Proulx, M; Das, SK; Pereira, O; Wang, W; Siddiqui, A; Yannopoulos, CG; Poisson, C; Turcotte, N; Drouin, A; Alaoui-Ismaili, MH; Bethell, R; Hamel, M; L'Heureux, L; Bilimoria, D; Nguyen-Ba, N Identification of N,N-disubstituted phenylalanines as a novel class of inhibitors of hepatitis C NS5B polymerase. J Med Chem 46:1283-5 (2003) [PubMed] Article
More Info.:
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
Inhibitor
Name:
BDBM50126676
Synonyms:
2-[4-(4'-Chloro-4-methoxy-biphenyl-2-ylmethoxy)-phenyl]-1-cyclohexyl-1H-benzoimidazole-5-carboxylic acid | 2-[4-(4'-chloro-4-methoxybiphenyl-2-ylmethoxy)phenyl]-1-cyclohexyl-1H-benzimidazole-5-carboxylic acid | CHEMBL24396
Type:
Small organic molecule
Emp. Form.:
C34H31ClN2O4
Mol. Mass.:
567.074
SMILES:
COc1ccc(c(COc2ccc(cc2)-c2nc3cc(ccc3n2C2CCCCC2)C(O)=O)c1)-c1ccc(Cl)cc1