Reaction Details Report a problem with these data
Target
Proteasome subunit beta type-8
Ligand
BDBM50007203
Substrate
n/a
Meas. Tech.
ChEMBL_2083255 (CHEMBL4739046)
IC50
59±n/a nM
Citation
 Wang, J; Liang, B; Chen, Y; Fuk-Woo Chan, J; Yuan, S; Ye, H; Nie, L; Zhou, J; Wu, Y; Wu, M; Huang, LS; An, J; Warshel, A; Yuen, KY; Ciechanover, A; Huang, Z; Xu, Y A new class of ?-ketoamide derivatives with potent anticancer and anti-SARS-CoV-2 activities. Eur J Med Chem 215:0 (2021) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-8
Synonyms:
26S proteosome | LMP7 | Low molecular mass protein 7 | Macropain subunit C13 | Multicatalytic endopeptidase complex subunit C13 | PSB8_HUMAN | PSMB5i | PSMB8 | Proteasome component C13 | Proteasome subunit beta type-8 | Proteasome subunit beta-5i | RING10 | Y2
Type:
PROTEIN
Mol. Mass.:
30357.49
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1446797
Residue:
276
Sequence:
MALLDVCGAPRGQRPESALPVAGSGRRSDPGHYSFSMRSPELALPRGMQPTEFFQSLGGDGERNVQIEMAHGTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSGCAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDKKGPGLYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEAYDLGRRAIAYATHRDSYSGGVVNMYHMKEDGWVKVESTDVSDLLHQYREANQ
  
Inhibitor
Name:
BDBM50007203
Synonyms:
CHEMBL3237875
Type:
Small organic molecule
Emp. Form.:
C31H40N4O7
Mol. Mass.:
580.6719
SMILES:
COc1ccc(C[C@H](NC(=O)[C@H](C)NC(=O)CN2CCOCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)[C@@]2(C)CO2)cc1 |r|
Structure:
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