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Target
Sodium- and chloride-dependent GABA transporter 3
Ligand
BDBM50039248
Substrate
n/a
Meas. Tech.
ChEMBL_2086314 (CHEMBL4767577)
IC50
1950±n/a nM
Citation
 Zar?ba, P; Gryz?o, B; Malawska, K; Sa?at, K; Höfner, GC; Nowaczyk, A; Fija?kowski, ?; Rapacz, A; Podkowa, A; Furga?a, A; ?mudzki, P; Wanner, KT; Malawska, B; Kulig, K Novel mouse GABA uptake inhibitors with enhanced inhibitory activity toward mGAT3/4 and their effect on pain threshold in mice. Eur J Med Chem 188:0 (2020) [PubMed]  Article 
Target
Name:
Sodium- and chloride-dependent GABA transporter 3
Synonyms:
GABA transporter | GAT-3 | Gabt3 | Gabt4 | Gat-4 | Gat3 | Gat4 | S6A11_MOUSE | Slc6a11 | Sodium- and chloride-dependent GABA transporter 3 | Sodium- and chloride-dependent GABA transporter 4 | Solute carrier family 6 member 11
Type:
PROTEIN
Mol. Mass.:
69962.73
Organism:
Mouse
Description:
ChEMBL_1460090
Residue:
627
Sequence:
MTAEQALPLGNGKAAEEARGSETLGGGGGGAAGTREARDKAVHERGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGITCWRRVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTEKCVEFQKLNFSNYSHVSLQNATSPVMEFWERRVLAISDGIEHIGNLRWELALCLLAAWTICYFCIWKGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWVDAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGVPIAEVAESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVFRRGYRRELLILALSIISYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECVCIGWVYGSNRFYDNIEDMIGYRPLSLIKWCWKVVTPGICAGIFIFFLVKYKPLKYNNVYTYPAWGYGIGWLMALSSMLCIPLWIFIKLWKTEGTLPEKLQKLTVPSADLKMRGKLGASPRTVTVNDCEAKVKGDGTISAITEKETHF
  
Inhibitor
Name:
BDBM50039248
Synonyms:
(R)-1-{2-[Tris-(4-methoxy-phenyl)-methoxy]-ethyl}-piperidine-3-carboxylic acid | CHEMBL419823
Type:
Small organic molecule
Emp. Form.:
C30H35NO6
Mol. Mass.:
505.602
SMILES:
COc1ccc(cc1)C(OCCN1CCC[C@H](C1)C(O)=O)(c1ccc(OC)cc1)c1ccc(OC)cc1
Structure:
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