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Target
Prostaglandin D2 receptor
Ligand
BDBM50060448
Substrate
n/a
Meas. Tech.
ChEMBL_157790 (CHEMBL878773)
IC50
71.0±n/a nM
Citation
Mitsumori, S; Tsuri, T; Honma, T; Hiramatsu, Y; Okada, T; Hashizume, H; Inagaki, M; Arimura, A; Yasui, K; Asanuma, F; Kishino, J; Ohtani, M Synthesis and biological activity of various derivatives of a novel class of potent, selective, and orally active prostaglandin D2 receptor antagonists. 1. Bicyclo[2.2.1]heptane derivatives. J Med Chem 46:2436-45 (2003) [PubMed] Article
More Info.:
Target
Name:
Prostaglandin D2 receptor
Synonyms:
PD2R_HUMAN | PTGDR | Prostaglandin D2 | Prostaglandin D2 receptor | Prostanoid DP receptor
Type:
Enzyme
Mol. Mass.:
40288.87
Organism:
Homo sapiens (Human)
Description:
Q13258
Residue:
359
Sequence:
MKSPFYRCQNTTSVEKGNSAVMGGVLFSTGLLGNLLALGLLARSGLGWCSRRPLRPLPSVFYMLVCGLTVTDLLGKCLLSPVVLAAYAQNRSLRVLAPALDNSLCQAFAFFMSFFGLSSTLQLLAMALECWLSLGHPFFYRRHITLRLGALVAPVVSAFSLAFCALPFMGFGKFVQYCPGTWCFIQMVHEEGSLSVLGYSVLYSSLMALLVLATVLCNLGAMRNLYAMHRRLQRHPRSCTRDCAEPRADGREASPQPLEELDHLLLLALMTVLFTMCSLPVIYRAYYGAFKDVKEKNRTSEEAEDLRALRFLSVISIVDPWIFIIFRSPVFRIFFHKIFIRPLRYRSRCSNSTNMESSL
Inhibitor
Name:
BDBM50060448
Synonyms:
(+) 7-[3-(2-Phenyl-1H-indole-6-sulfonylamino)-bicyclo[2.2.1]hept-2-yl]-hept-5-enoic acid | (Z)-7-[(1S,2R,3R,4R)-3-(2-Phenyl-1H-indole-6-sulfonylamino)-bicyclo[2.2.1]hept-2-yl]-hept-5-enoic acid | CHEMBL312697
Type:
Small organic molecule
Emp. Form.:
C28H32N2O4S
Mol. Mass.:
492.63
SMILES:
OC(=O)CCC\C=C/C[C@@H]1[C@H]2CC[C@H](C2)[C@H]1NS(=O)(=O)c1ccc2cc([nH]c2c1)-c1ccccc1