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Target
Platelet-derived growth factor receptor beta
Ligand
BDBM50568078
Substrate
n/a
Meas. Tech.
ChEMBL_2104430 (CHEMBL4812933)
IC50
4800±n/a nM
Citation
 Yang, WS; Qi, XR; Xu, QZ; Yuan, CH; Yi, YH; Tang, HF; Shen, L; Han, H A new sulfated triterpene glycoside from the sea cucumber Colochirus quadrangularis, and evaluation of its antifungal, antitumor and immunomodulatory activities. Bioorg Med Chem 41:0 (2021) [PubMed]  Article 
Target
Name:
Platelet-derived growth factor receptor beta
Synonyms:
2.7.10.1 | Beta platelet-derived growth factor receptor | Beta-type platelet-derived growth factor receptor | CD140 antigen-like family member B | CD140b antigen | CD_antigen=CD140b | PDGF-R-beta | PDGFR-1 | PDGFR-beta | PGFRB_MOUSE | Pdgfr | Pdgfr1 | Pdgfrb | Platelet-Derived Growth Factor Receptor, beta | Platelet-derived growth factor receptor | Platelet-derived growth factor receptor 1
Type:
Enzyme
Mol. Mass.:
122771.00
Organism:
Mus musculus (mouse)
Description:
P05622
Residue:
1098
Sequence:
MGLPGVIPALVLRGQLLLSVLWLLGPQTSRGLVITPPGPEFVLNISSTFVLTCSGSAPVMWEQMSQVPWQEAAMNQDGTFSSVLTLTNVTGGDTGEYFCVYNNSLGPELSERKRIYIFVPDPTMGFLPMDSEDLFIFVTDVTETTIPCRVTDPQLEVTLHEKKVDIPLHVPYDHQRGFTGTFEDKTYICKTTIGDREVDSDTYYVYSLQVSSINVSVNAVQTVVRQGESITIRCIVMGNDVVNFQWTYPRMKSGRLVEPVTDYLFGVPSRIGSILHIPTAELSDSGTYTCNVSVSVNDHGDEKAINISVIENGYVRLLETLGDVEIAELHRSRTLRVVFEAYPMPSVLWLKDNRTLGDSGAGELVLSTRNMSETRYVSELILVRVKVSEAGYYTMRAFHEDDEVQLSFKLQVNVPVRVLELSESHPANGEQTIRCRGRGMPQPNVTWSTCRDLKRCPRKLSPTPLGNSSKEESQLETNVTFWEEDQEYEVVSTLRLRHVDQPLSVRCMLQNSMGGDSQEVTVVPHSLPFKVVVISAILALVVLTVISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPVQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQRHSNKHCPPSAELYSNALPVGFSLPSHLNLTGESDGGYMDMSKDESIDYVPMLDMKGDIKYADIESPSYMAPYDNYVPSAPERTYRATLINDSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARFPGIHSLRSPLDTSSVLYTAVQPNESDNDYIIPLPDPKPDVADEGLPEGSPSLASSTLNEVNTSSTISCDSPLELQEEPQQAEPEAQLEQPQDSGCPGPLAEAEDSFL
  
Inhibitor
Name:
BDBM50568078
Synonyms:
CHEMBL4865518
Type:
Small organic molecule
Emp. Form.:
C55H85NaO25S
Mol. Mass.:
1201.303
SMILES:
[Na;v0+].[H][C@]12[#6@H](-[#6][C@@]3([#6])[#6]4=[#6]-[#6]-[#6]5C([#6])([#6])[C@]([H])([#6]-[#6][C@]5([#6])[C@]4([H])[#6]-[#6][C@]13[#6](=O)-[#8][C@@]2([#6])[#6]-[#6]-[#6]-[#6](-[#6])=[#6])[#8]-[#6@@H]1-[#8]-[#6]-[#6@@H](-[#8]S([#8-])(=O)=O)-[#6@H](-[#8])[C@@]1([H])[#8]-[#6@@H]-1-[#8]-[#6@H](-[#6])-[#6@@H](-[#8][C@]2([H])[#8]-[#6]-[#6@@H](-[#8])-[#6@H](-[#8][C@]3([H])[#8]-[#6@H](-[#6]-[#8])-[#6@@H](-[#8])-[#6@H](-[#8]-[#6])-[#6@H]3-[#8])-[#6@H]2-[#8])-[#6@H](-[#8])-[#6@H]-1-[#8])-[#8]-[#6](-[#6])=O |r,t:6|
Structure:
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