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Target
Pancreatic triacylglycerol lipase
Ligand
BDBM50569168
Substrate
n/a
Meas. Tech.
ChEMBL_2108317 (CHEMBL4816992)
IC50
5900±n/a nM
Citation
 Zhang, R; Song, Z; Wang, X; Xue, J; Xing, D One-step modification to identify dual-inhibitors targeting both pancreatic triglyceride lipase and Niemann-Pick C1-like 1. Eur J Med Chem 216:0 (2021) [PubMed]  Article 
Target
Name:
Pancreatic triacylglycerol lipase
Synonyms:
LIPP_HUMAN | PL | PNLIP | Pancreatic lipase
Type:
PROTEIN
Mol. Mass.:
51157.75
Organism:
Homo sapiens (Human)
Description:
ChEMBL_527250
Residue:
465
Sequence:
MLPLWTLSLLLGAVAGKEVCYERLGCFSDDSPWSGITERPLHILPWSPKDVNTRFLLYTNENPNNFQEVAADSSSISGSNFKTNRKTRFIIHGFIDKGEENWLANVCKNLFKVESVNCICVDWKGGSRTGYTQASQNIRIVGAEVAYFVEFLQSAFGYSPSNVHVIGHSLGAHAAGEAGRRTNGTIGRITGLDPAEPCFQGTPELVRLDPSDAKFVDVIHTDGAPIVPNLGFGMSQVVGHLDFFPNGGVEMPGCKKNILSQIVDIDGIWEGTRDFAACNHLRSYKYYTDSIVNPDGFAGFPCASYNVFTANKCFPCPSGGCPQMGHYADRYPGKTNDVGQKFYLDTGDASNFARWRYKVSVTLSGKKVTGHILVSLFGNKGNSKQYEIFKGTLKPDSTHSNEFDSDVDVGDLQMVKFIWYNNVINPTLPRVGASKIIVETNVGKQFNFCSPETVREEVLLTLTPC
  
Inhibitor
Name:
BDBM50569168
Synonyms:
CHEMBL4847071
Type:
Small organic molecule
Emp. Form.:
C30H48O5
Mol. Mass.:
488.6991
SMILES:
CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)c1ccc(OC)cc1 |r|
Structure:
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