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Target
Cyclin-C
Ligand
BDBM50573489
Substrate
n/a
Meas. Tech.
ChEMBL_2119597 (CHEMBL4828663)
IC50
6.0±n/a nM
Citation
 Hatcher, JM; Vatsan, PS; Wang, E; Jiang, J; Gray, NS Development of Highly Potent and Selective Pyrazolopyridine Inhibitor of CDK8/19. ACS Med Chem Lett 12:1689-1693 (2021) [PubMed]  Article 
Target
Name:
Cyclin-C
Synonyms:
CCNC | CCNC_HUMAN | Cyclin C | SRB11 homolog | hSRB11
Type:
PROTEIN
Mol. Mass.:
33244.88
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107900
Residue:
283
Sequence:
MAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFFTNVIQALGEHLKLRQQVIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASKVEEFGVVSNTRLIAAATSVLKTRFSYAFPKEFPYRMNHILECEFYLLELMDCCLIVYHPYRPLLQYVQDMGQEDMLLPLAWRIVNDTYRTDLCLLYPPFMIALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLYEQWKNFDERKEMATILSKMPKPKPPPNSEGEQGPNGSQNSSYSQS
  
Inhibitor
Name:
BDBM50573489
Synonyms:
CHEMBL4878356
Type:
Small organic molecule
Emp. Form.:
C22H22N6O
Mol. Mass.:
386.4497
SMILES:
Cn1ncc2cc(ccc12)-c1cnc2[nH]ccc2c1N1CCC2(CNC2=O)CC1
Structure:
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