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Target
Syndecan-2
Ligand
BDBM50574551
Substrate
n/a
Meas. Tech.
ChEMBL_2122626 (CHEMBL4831859)
IC50
112000±n/a nM
Citation
 Garcia, M; Hoffer, L; Leblanc, R; Benmansour, F; Feracci, M; Derviaux, C; Egea-Jimenez, AL; Roche, P; Zimmermann, P; Morelli, X; Barral, K Fragment-based drug design targeting syntenin PDZ2 domain involved in exosomal release and tumour spread. Eur J Med Chem 223:0 (2021) [PubMed]  Article 
Target
Name:
Syndecan-2
Synonyms:
CD_antigen=CD362 | Fibroglycan | HSPG | HSPG1 | Heparan sulfate proteoglycan core protein | SDC2 | SDC2_HUMAN | SYND2 | Syndecan-2
Type:
PROTEIN
Mol. Mass.:
22149.57
Organism:
Homo sapiens
Description:
ChEMBL_120518
Residue:
201
Sequence:
MRRAWILLTLGLVACVSAESRAELTSDKDMYLDNSSIEEASGVYPIDDDDYASASGSGADEDVESPELTTSRPLPKILLTSAAPKVETTTLNIQNKIPAQTKSPEETDKEKVHLSDSERKMDPAEEDTNVYTEKHSDSLFKRTEVLAAVIAGGVIGFLFAIFLILLLVYRMRKKDEGSYDLGERKPSSAAYQKAPTKEFYA
  
Inhibitor
Name:
BDBM50574551
Synonyms:
CHEMBL4866317
Type:
Small organic molecule
Emp. Form.:
C22H28N2O5S
Mol. Mass.:
432.533
SMILES:
COCCOc1ccc(cn1)-c1ccc(SCCC(=O)N[C@@H](C(C)C)C(O)=O)cc1 |r|
Structure:
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