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Target
Histone deacetylase 1
Ligand
BDBM50576424
Substrate
n/a
Meas. Tech.
ChEMBL_2127169 (CHEMBL4836514)
IC50
280±n/a nM
Citation
 Padilla-Coley, S; Rudebeck, EE; Smith, BD; Pfeffer, FM Intracellular fluorescence competition assay for inhibitor engagement of histone deacetylase. Bioorg Med Chem Lett 47:0 (2021) [PubMed]  Article 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50576424
Synonyms:
CHEMBL4864538
Type:
Small organic molecule
Emp. Form.:
C26H23F3N2O5
Mol. Mass.:
500.4664
SMILES:
ONC(=O)CCCCCN1C(=O)c2cccc3c(OCc4ccc(cc4)C(F)(F)F)ccc(C1=O)c23
Structure:
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