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Target
Protein AF-9
Ligand
BDBM50576674
Substrate
n/a
Meas. Tech.
ChEMBL_2127680 (CHEMBL4837025)
IC50
410±n/a nM
Citation
 Jiang, Y; Liu, S; Tian, G; Cheung, HJH; Li, X; Li, XD Concise solid-phase synthesis enables derivatisation of YEATS domain cyclopeptide inhibitors for improved cellular uptake. Bioorg Med Chem 45:0 (2021) [PubMed]  Article 
Target
Name:
Protein AF-9
Synonyms:
AF9 | AF9_HUMAN | ALL1-fused gene from chromosome 9 protein | MLLT3 | Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein | Protein AF-9 | YEATS domain-containing protein 3 | YEATS3
Type:
PROTEIN
Mol. Mass.:
63368.78
Organism:
Homo sapiens
Description:
ChEMBL_118006
Residue:
568
Sequence:
MASSCAVQVKLELGHRAQVRKKPTVEGFTHDWMVFVRGPEHSNIQHFVEKVVFHLHESFPRPKRVCKDPPYKVEESGYAGFILPIEVYFKNKEEPRKVRFDYDLFLHLEGHPPVNHLRCEKLTFNNPTEDFRRKLLKAGGDPNRSIHTSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTSFSKPHKLMKEHKEKPSKDSREHKSAFKEPSRDHNKSSKESSKKPKENKPLKEEKIVPKMAFKEPKPMSKEPKPDSNLLTITSGQDKKAPSKRPPISDSEELSAKKRKKSSSEALFKSFSSAPPLILTCSADKKQIKDKSHVKMGKVKIESETSEKKKSTLPPFDDIVDPNDSDVEENISSKSDSEQPSPASSSSSSSSSFTPSQTRQQGPLRSIMKDLHSDDNEEESDEVEDNDNDSEMERPVNRGGSRSRRVSLSDGSDSESSSASSPLHHEPPPPLLKTNNNQILEVKSPIKQSKSDKQIKNGECDKAYLDELVELHRRLMTLRERHILQQIVNLIEETGHFHITNTTFDFDLCSLDKTTVRKLQSYLETSGTS
  
Inhibitor
Name:
BDBM50576674
Synonyms:
CHEMBL4850575
Type:
Small organic molecule
Emp. Form.:
C37H55N11O10
Mol. Mass.:
813.9003
SMILES:
[H][C@]1(NC(=O)[C@H](CCCCNC(=N)NCCC[C@@H](NC(=O)[C@H](C)NC1=O)C(=O)N[C@@H](CCCCNC(=O)c1cnco1)C(N)=O)NC(=O)OCc1ccccc1)[C@H](C)O |r|
Structure:
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