Reaction Details Report a problem with these data
Target
Neuromedin-B receptor
Ligand
BDBM50147019
Substrate
n/a
Meas. Tech.
ChEMBL_143204 (CHEMBL752221)
IC50
29±n/a nM
Citation
Shuttleworth, SJ; Lizarzaburu, ME; Chai, A; Coward, P Identification and optimization of novel partial agonists of neuromedin B receptor using parallel synthesis. Bioorg Med Chem Lett 14:3037-42 (2004) [PubMed] Article
More Info.:
Target
Name:
Neuromedin-B receptor
Synonyms:
Bombesin 1 | NMB-R | NMBR | NMBR_HUMAN | Neuromedin B | Neuromedin B receptor | Neuromedin-B receptor | Neuromedin-B-preferring bombesin receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
43447.11
Organism:
Human
Description:
Bombesin 1 NMBR 0::P28336
Residue:
390
Sequence:
MPSKSLSNLSVTTGANESGSVPEGWERDFLPASDGTTTELVIRCVIPSLYLLIITVGLLGNIMLVKIFITNSAMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWMFGKVGCKLIPVIQLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGALLRTCVKAMGIWVVSVLLAVPEAVFSEVARISSLDNSSFTACIPYPQTDELHPKIHSVLIFLVYFLIPLAIISIYYYHIAKTLIKSAHNLPGEYNEHTKKQMETRKRLAKIVLVFVGCFIFCWFPNHILYMYRSFNYNEIDPSLGHMIVTLVARVLSFGNSCVNPFALYLLSESFRRHFNSQLCCGRKSYQERGTSYLLSSSAVRMTSLKSNAKNMVTNSVLLNGHSMKQEMAL
Inhibitor
Name:
BDBM50147019
Synonyms:
3-[3-(2,6-Diisopropyl-phenyl)-ureido]-5-methoxy-2,3,4,9-tetrahydro-1H-carbazole-3-carboxylic acid (1-pyridin-2-yl-cyclohexylmethyl)-amide | CHEMBL103756
Type:
Small organic molecule
Emp. Form.:
C39H49N5O3
Mol. Mass.:
635.8381
SMILES:
COc1cccc2[nH]c3CCC(Cc3c12)(NC(=O)Nc1c(cccc1C(C)C)C(C)C)C(=O)NCC1(CCCCC1)c1ccccn1